Unknowns

Drugs pipeline
GSK spends about £3.5 bn per year on R&D. Much of it comes to nothing. Like all big pharmaceutical companies, GSK hope that a small portion of the spending will result in a few marketable drugs that will generate sufficient profits to give a reasonable overall return to shareholders commensurate with the risk they bear. But neither GSK nor anybody else knows as to which portion of the spend will be successful

Forex rates movements (specially $)